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KMID : 0614620150660040231
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Korean Journal of Gastroenterology
2015 Volume.66 No. 4 p.231 ~ p.236
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A Case of Crohn’s Disease Showing Favorable Response to Induction and Maintenance Therapy with Methotrexate after Failure of Anti-tumor Necrosis Factor Therapy
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최정란:Choi Jung-Ran
윤각원:Yun Gak-Won/박유미:Park Yoo-Mi/김지현:Kim Jie-Hyun/윤영훈:Yoon Young-Hoon/박효진:Park Hyo-Jin/박재준:Park Jae-Jun
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Abstract
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Thanks to the introduction of immumomodulators and biologics, therapeutic approaches in Crohn’s disease have changed significantly during the past decade. Although new biologic therapy has dramatically improved the treatment of Crohn’s disease, a substantial number of patients are refractory to these therapies or lose their initial response. Methotrexate (MTX) is a structural analogue of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase and has been widely used as immunomodulator in rheumatology area for patients with rheumatoid arthritis and psoriasis. Although MTX has also been shown to be an effective agent for remission induction and maintenance of remission in Crohn’sdisease, the use of MTX in Crohn’s disease has not yet been reported in Korea. Herein, we report a case of Crohn’s disease patient who was successfully treated with MTX after treatment failure with thiopurine and anti-tumor necrosis factor.
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KEYWORD
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Methotrexate, Maintenance, Crohn disease, Remission induction
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